Package: diffHTS
Type: Package
Title: Differential Drug Sensitivity Analysis for Two-Condition
        High-Throughput Screens
Version: 0.1.0
Authors@R: 
    person("Liang", "Tang", email = "xphdtangliang@gmail.com", role = c("aut", "cre"))
Description: A complete workflow for large-scale, two-condition
        high-throughput drug screening (HTS). It compares drug
        sensitivity between any two experimental conditions - for
        example irradiated versus non-irradiated cells, cancer versus
        normal cell lines, or treated versus untreated samples - across
        many plates and experiments. The package covers the full
        pipeline: control-based normalisation, plate-level
        quality-control metrics (Z-factor, Z-prime,
        signal-to-background, signal-to-noise and strictly standardised
        mean difference), replicate-consistency checks, four-parameter
        logistic dose-response fitting with area under the curve (AUC)
        estimation, differential (delta) AUC scoring with within-plate
        standardisation, cut-off and sigma-based hit selection, and
        publication-ready heatmap, scatter and quality-control
        visualisations.
License: GPL-3
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1)
Imports: tidyr, rlang, ggplot2, graphics, stats, utils
Suggests: ComplexHeatmap, circlize, ggprism, ggrepel, grid, readxl,
        testthat (>= 3.0.0), knitr, rmarkdown
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
NeedsCompilation: no
Packaged: 2026-09-27 08:46:31 UTC; root
Author: Liang Tang [aut, cre]
Maintainer: Liang Tang <xphdtangliang@gmail.com>
Config/pak/sysreqs: libicu-dev
Repository: https://kongjianyang.r-universe.dev
Date/Publication: 2026-07-28 16:10:08 UTC
RemoteUrl: https://github.com/cran/diffHTS
RemoteRef: HEAD
RemoteSha: 67aacbc0505a58ec8a1a04573ff36e297e95b633