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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "diffHTS" in publications use:'
type: software
license: GPL-3.0-only
title: 'diffHTS: Differential Drug Sensitivity Analysis for Two-Condition High-Throughput
  Screens'
version: 0.1.0
doi: 10.32614/CRAN.package.diffHTS
abstract: 'A complete workflow for large-scale, two-condition high-throughput drug
  screening (HTS). It compares drug sensitivity between any two experimental conditions
  - for example irradiated versus non-irradiated cells, cancer versus normal cell
  lines, or treated versus untreated samples - across many plates and experiments.
  The package covers the full pipeline: control-based normalisation, plate-level quality-control
  metrics (Z-factor, Z-prime, signal-to-background, signal-to-noise and strictly standardised
  mean difference), replicate-consistency checks, four-parameter logistic dose-response
  fitting with area under the curve (AUC) estimation, differential (delta) AUC scoring
  with within-plate standardisation, cut-off and sigma-based hit selection, and publication-ready
  heatmap, scatter and quality-control visualisations.'
authors:
- family-names: Tang
  given-names: Liang
  email: xphdtangliang@gmail.com
repository: https://kongjianyang.r-universe.dev
commit: 67aacbc0505a58ec8a1a04573ff36e297e95b633
date-released: '2026-07-28'
contact:
- family-names: Tang
  given-names: Liang
  email: xphdtangliang@gmail.com